Long noncoding RNA NEAT1 mediates neuronal histone methylation and age-related memory impairment
نویسندگان
چکیده
منابع مشابه
Boundary Associated Long Noncoding RNA Mediates Long-Range Chromosomal Interactions
CCCTC binding factor (CTCF) is involved in organizing chromosomes into mega base-sized, topologically associated domains (TADs) along with other factors that define sub-TAD organization. CTCF-Cohesin interactions have been shown to be critical for transcription insulation activity as it stabilizes long-range interactions to promote proper gene expression. Previous studies suggest that heterochr...
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Paraspeckles are subnuclear structures formed around nuclear paraspeckle assembly transcript 1 (NEAT1)/MENε/β long noncoding RNA (lncRNA). Here we show that paraspeckles become dramatically enlarged after proteasome inhibition. This enlargement is mainly caused by NEAT1 transcriptional up-regulation rather than accumulation of undegraded paraspeckle proteins. Of interest, however, using immuno-...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2019
ISSN: 1945-0877,1937-9145
DOI: 10.1126/scisignal.aaw9277